Pharmacogenetic (PGx) Testing

Pharmacogenetic testing (a.k.a. “PGx Testing”) is a diagnostic tool that tests specific DNA sequence variations in patients.  The focus is on a family of genes with a key role in metabolizing prescribed medications.  Collectively, these genes are known as Cytochrome P450 (CYP450) genes.  These genes code for enzymes that convert inactive pro-drugs into their active compounds, or break down active drugs into inactive metabolites for excretion.  By testing the single nucleotide polymorphisms (SNPs) associated with these genes the lab is able to identify a patient’s genotype and their resulting phenotype. Every patient has a metabolism phenotype for each of the CYP450 genes/proteins, based on the genotype of each gene.  The phenotype possibilities include:

  • Ultra/rapid metabolizer
  • Normal metabolizer
  • Intermediate metabolizer
  • Poor metabolizer

PGx testing incorporates the latest clinical research to make determinations about how a patient is likely to metabolize, and thus, respond to specific medications.  A physician with this information may determine the following regarding a patient’s response to medications:

  • Whether the medication is likely to be effective vs. ineffective
  • Whether the patient may need a dose reduction or a dose escalation
  • Whether a medication may cause adverse events

The PGx report provides information that is either “actionable or informative”. The medications reported on are classified into one of the following groups:

  • Use with standard precautions
  • Use with caution
  • Consider alternatives

The goal with PGx testing is to provide the right drug, to the right patient, at the right dose.

Medication Monitoring

Insight Diagnostics pledges to help practitioners use drug screening medication monitoring to reduce risk to your patients, improving the quality of your care, reducing costs, and satisfying the demand for patient-centered care. In response to the ever-changing healthcare environment, we are committed to providing superior technology, products, and services to our clients.

Insight Diagnostics’ state-of-the-art laboratories combine cutting-edge technology with world-class customer service. We are dedicated to satisfying your particular demands with customized drug monitoring solutions.

Addiction and Treatment

A comprehensive testing program requires a full battery of lab services, unsurpassed accuracy, and around-the-clock support from an experienced team of experts. Insight Diagnostics’ LC/MS/MS (liquid chromatography/dual mass spectrometry), our industry’s gold standard, covers the most comprehensive list of drugs to help determine patient adherence to the treatment program you prescribe.

Our customized testing offers the highest levels of reliability, integrity, and transparency; timely reporting, and 24/7 access to our toxicologists; and compliance with evidence-based guidelines and government-mandated regulations.